Objective: To investigate the effect of abnormal ovarian granulosa cell metabolism on in vitro fertilization and embryo transfer (IVF-ET) outcomes in obese polycystic ovary syndrome (PCOS) patients. Methods: Patients with PCOS who met the study criteria were screened according to the inclusion criteria. A total of 32 patients with obese PCOS were recruited into the study group, and 39 patients with non-obese PCOS were recruited into the control group. The general data (age, body mass index, and years of infertility), insulin resistance index (HOMA-IR), follicle-stimulating hormone (FSH), luteinizing hormone (LH), granulosa cell mitochondrial function, and IVF-ET outcome of patients in the study group and control group were retrospectively analyzed. Results: The differences in age and years of infertility between the study group and the control group were insignificant (P > 0.05), and the body mass index (BMI) of the study group and control group was 30.5 ± 1.24 kg/m2 and 22.3 ± 1.12 kg/m2, respectively, in which the difference was statistically significant (P < 0.05); the HOMA-IR of the study group was significantly higher than that of the control group (P < 0.05); the reactive oxygen species (ROS) in the study group was significantly higher than that in the control group (P < 0.05), and the ATP content in the study group was significantly lower than that in the control group (P < 0.05); comparing the FSH and LH levels between the two groups, the difference was not statistically significant (P > 0.05); the rate of IVF-ET failure was significantly higher in the study group than in the control group. Conclusion: PCOS is a complex endocrine disorder, and obesity is one of the independent risk factors for the development of PCOS.
Yu C, Dai X, Wang Y, et al., 2019, Effects of PPOS on IVF-ET Outcomes in Patients with Hypoovarian Function in Different Age Groups. Maternal and Child Health Care in China, 2019(17): 4043–4045.
Zhong X, 2019, Prediction Value of Follicular Fluid AMH, BMP-15 and ActivinA for IVF-ET Outcome and Ovarian Reactivity, thesis, Nanchang University.
Niu L, Tian J, Li J, et al., 2019, Relationship Between Concentration of hCG and AMH in Follicular Fluid and Outcome of IVF-ET. International Journal of Laboratory Medicine, 40(06):703–706.
Hou G, Sun X, Qiao Y, et al., 2019, Correlation Analysis Between Vitamin D and IVF-ET Outcome. Chinese Journal of Eugenics and Genetics, 27(02): 251–253.
Liu Z, 2019, Research Progress in Evaluating the Outcome of IVF-ET by Detecting Endometrial Blood Flow with Color Doppler Energy Graph. Journal of Medical Information, 32(03): 52–54.
Luo X, Zhou C, Zhou Y, 2018, Relationship of MMP-9 and Its Inhibitor TIMP-1 with Embryo Quality and IVF-ET Outcome in Human Embryo Culture Medium. Chinese Clinical Research, 31(08): 1020–1024.
Xu G, Zhang L, 2017, Relationship Between Endometrial Blood Flow and IVF-ET Outcomes in Pre-Implantation Period. World Latest Medical Information Abstract, 17(84): 173.
Gong Y, Zhou L, Cai J, et al., 2017, Effects of Dehydroepiandrosterone on Ovarian Reactivity and IVF-ET Outcomes in Patients with Decreased Ovarian Reserve Function. Journal of Reproductive Medicine, 26(07): 675–678.
Wang Y, 2017, Effects of Follicle Output Rate on Ovarian Reactivity and IVF-ET Outcome in Infertility Patients with Endometriosis, thesis, Anhui Medical University.
Wang J, 2016, Clinical Study on the Correlation Between PGE2 Levels in Follicular Fluid and IVF-ET Outcomes in Infertile Patients with Endometriosis, thesis, Hebei Medical University.
Cai P, 2016, Study on the Relationship Between Telomere Length of Granulosa Cells and Oocyte Maturity and IVF-ET Outcome in Follicular Fluid, thesis, Zhengzhou University.
Yan M, 2016, Effects of Luteinizing Hormone Levels on IVF-ET Outcomes in Patients with Polycystic Ovary Syndrome During Long Regimen Controlled Hyperovulation, thesis, Southern Medical University.
Zhou W, Xiong Y, Yang G, et al., 2016, Comparison of Different Dosages of Follicle Stimulating Hormone on IVF-ET Outcomes in 35-Year-Old Women. Chinese Medical Innovation, 13(4): 13 + 16.
Ding J, Yang J, Zhao M, et al., 2016, Relationship Between the Ratio of Serum Progesterone Level to Follicle Number with Diameter ? 14mm and IVF-ET Outcome on hCG Day. International Journal of Reproductive Health/Family Planning, 35(01): 13 + 16.
Tang Z, 2015, Relationship Between Perifollicular Blood Flow Parameters and Oocyte Maturity and IVF-ET Outcome, thesis, Kunming Medical University.