Objective: To investigate the TCM treatment principle of membranous nephropathy and its effect. Methods: A total of 56 patients were selected from the Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine. They were then divided into the control group (western medicine standard therapy) and the study group (Qidi Gushen prescription), with 28 patients in each group. The treatment effect, treatment safety, and patients’ satisfaction were observed and compared between the two groups. Results: The results showed that the treatment effect of the study group was 96.43%, which was significantly better compared with the control group (75.00%) (p < 0.05); in terms of safety, the probability of adverse events was 7.14% in the study group and 32.14% in the control group, in which the difference was statistically significant (p < 0.05); in addition, the study group’s satisfaction with the treatment measures was significantly higher than that of the control group (p < 0.05). Conclusion: In treating membranous nephropathy, traditional Chinese medicine can be tailored to its pathogenesis, which is not only beneficial to the treatment effect, but also has a high safety profile.
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