Pregnancy and Childbirth After Sertoli-Leydig Cell Tumor Resection: A Case Study and Literature Review


Ovarian tumor
Sertoli-Leydig cell tumor




Objectives: To explore the clinical manifestations and pathological features in the biopsy of ovarian Sertoli-Leydig cell tumor, as well as to improve the clinical understanding of the disease. Methods: A case of pregnancy and childbirth after Sertoli-Leydig cell tumor resection was retrospectively analyzed. The patients’ clinical data were collected, including the clinical manifestations, postoperative biopsy results, auxiliary examination results, immunohistochemical results, treatment, and prognosis of the patient. Results: (1) SLCT occurred unilaterally; (2) according to the International Federation of Obstetrics and Gynecology (FIGO), the clinical staging was stage IA; according to the pathological classification of malignant tumors, it was grade ? (moderately differentiated); (3) a healthy female live baby was delivered. Conclusion: Such tumors are rare low-grade malignancies and are even rarer in pregnancy. An increase in preoperative testosterone levels with positive ultrasonography results can be used to assist diagnosis; however, postoperative biopsy pathology remains the “gold standard” for the diagnosis of SLCTs. The definite diagnosis of SLCTs is of great significance for surgical planning and prognostic evaluation.


Xie X, Kong B, Duan T, 2018, Obstetrics and Gynecology Ninth Edition, People’s Health Publishing House, Beijing, 320–321.

Du X, Lin X, 2018, Ovarian Support – Clinicopathological Analysis of 12 Cases of Stromal Cell Tumor. Chinese Medicine Guide, 16(34): 108–109.

Guo L, Chen H, 2018, A Case Report of Ovarian Support-Stromal Cell Tumor and Literature Review. China Family Planning and Obstetrics, 10(11): 92–94.

Ding C, Li Z, Yuan Y, et al., 2019, Clinicopathological Analysis of 6 Cases of Ovarian Support-Stromal Cell Tumor. Modern Oncology, 27(23): 4264–4268.

Yang N, 2018, Ovarian Support – Analysis of Clinical Features and Prognostic Factors of Stromal Cell Tumors. Peking Union Medical College.

Liu X, Zhao Q, Liu H, 2018, Clinical Analysis of Ovarian Sertoli Cell-Stromal Cell Tumor. Chinese Journal of Clinical Medicine for Women and Children, 14(05): 508–514.

Chen J, Wang Y, Chen H, et al., 2020, CT Diagnosis and Clinicopathological Features of Ovarian Support-Stromal Cell Tumors. Chinese Journal of Integrative Medicine Imaging, 18(06): 609–611.

DiSaia PJ, Creasman WT, 1997, Germ Cell, Stromal and Other Ovarian Tumor, in Clinical Gynecologic Oncology, Mosby-Yearbook, 351.

Wang Y, Jiang H, Wang X, 2008, A Case of Spontaneous Pregnancy and Childbirth After Excision of Ovarian Orchioblastoma. Chinese Journal of Perinatal Medicine, 3(2): 143–144.