Research Progress on the Effect of Sphingosine Kinase 2 on Glioma
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Keywords

Glioma
SphK2
Diagnosis
Biomarker

DOI

10.26689/par.v5i6.2763

Submitted : 2021-10-31
Accepted : 2021-11-15
Published : 2021-11-30

Abstract

Objective: The purpose of this study is to explore the role of sphingosine kinase 2 (SphK2) in the treatment of glioma, which is the most common primary tumor in the central nervous system. Methods: A total of 82 patients were included in this study, with 27 cases in the control group and 55 cases in the glioma group; the expressions of SphK2 and gp130 in the two groups were compared by immunohistochemical method, and the correlation between the two factors was analyzed. Results: Both SphK2 and gp130 were upregulated in the glioma group, and the two factors were significantly correlated. Conclusion: The high expression of SphK2 may play an important role in the occurrence, development, and diagnosis of glioma.

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