Keywords
Hemophagocytic lymphohistiocytosis
Submitted : 2021-08-31
Accepted : 2021-09-15
Published : 2021-09-30
Abstract
The article discusses a case of severe tsutsugamushi disease complicated with hemophagocytic syndrome in Guangdong Maternal and Child Health Hospital and concludes that blood purification technology has significant therapeutic effect among children with severe HLH complicated with multiple organ dysfunction.
References
Amano K, Tamura A, Ohashi N, et al., 2987, Deficiency of Peptidoglycan and Lipopolysaccharide Components in Rickettsia Tsutsugamushi. Infect Immun, 55: 2290-2292.
Paris DH, Shelite TR, Day NP, et al., 2013, Unresolved Problems Related to Scrub Typhus: A Seriously Neglected Life-Threatening Disease. Am J Trop Med Hyg, 89: 301-307. 10.4269/ajtmh.13-0064
Xu G, Walker DH, Jupiter D, et al., 2017, A Review of the Global Epidemiology of Scrub Typhus. PLoS Negl Trop Dis, 11(11): e0006062. 10.1371/journal.pntd.0006062
Cascio A, Correnti P, Iaria C, 2013, Scrub Typhus, Acute Respiratory Distress, and Hemophagocytic Lymphohistiocytosis. Int J Infect Dis, 17: e662. 10.1016/j.ijid.2013.03.006
Bonell A, Lubell PN, Newton JA, et al., 2017, Estimating the Burden of Scrub Typhus: A Systematic Review. PLoS Negl Trop Dis, 11: e0005838. 10.1371/journal.pntd.0005838
Usmani GN, Woda BA, Newburger PE, 2013, Advances in Understanding the Pathogenesis of HLH. Br J Haematol, 161: 609-622.
Agrwal S, Dabas A, Mantan M, et al., 2019, Hemophagocytic Lymphohistiocytosis with Neurological Manifestations in an Infant with Scrub Typhus: A Rare Fatal Occurrence. Trop Doct, 49(1): 52-53. 10.1177/0049475518804696
Basu A, Chowdhoury SR, Sarkar M, et al., 2021, Scrub Typhus-Associated Hemophagocytic Lymphohistiocytosis. J Trop Pediatr, 67(1): 1-10. 10.1093/tropej/fmab001
Paris DH, Shelite TR, Day NP, et al., 2013, Unresolved Problems Related to Scrub Typhus: A Seriously Neglected Life-Threatening Disease. Am J Trop Med Hyg, 89(2): 301-307. 10.4269/ajtmh.13-0064
Park JW, Kim SH, Park DW, et al., 2018, Molecular Epidemiology of an Orientia Tsutsugamushi Gene Encoding a 56-Kda Type-Specific Antigen in Chiggers, Small Mammals, and Patients from the Southwest Region of Korea. Am J Trop Med Hyg, 98(2): 616-624. 10.4269/ajtmh.17-0070
Qi Y, Yin Q, Shao Y, et al., 2018, Development of a Rapid and Visual Nucleotide Detection Method for A Chinese Epidemic Strain of Orientia Tsutsugamushi Based on Recombinase Polymerase Amplification Assay and Lateral Flow Test. Int J Infect Dis, 70: 42-50. 10.1016/j.ijid.2018.03.003
Yue Y, Wang Y, Li G, et al., 2020, Epidemiological Characteristics of Tsutsugamushi Disease in Chinese Mainland from 2006 to 2018. Surveillance, 35(4): 301-306. 10.3784/j.issn.1003-9961.2020.04.007
Gautam R, Parajuli K, Tshokey T, et al., 2020, Diagnostic Evaluation of IgM ELISA and IgM Immunofluorescence Assay for the Diagnosis of Acute Scrub Typhus in Central Nepal. BMC Infect Dis, 20(1): 138. 10.1186/s12879-020-4861-y
Valbuena G, Walker DH, 2013, Approaches to Vaccines Against Orientia Tsutsugamushi. Cell Infect Microbiol, 2: 1-18. 10.3389/fcimb.2012.00170
Yasunaga H, Horiguchi H, Kuwabara K, et al., 2011, Delay in Tetracycline Treatment Increases the Risk of Complications in Tsutsugamushi Disease: Data from the Japanese Diagnosis Procedure Combination Database. Intern Med, 50(1): 37-42. 10.2169/internalmedicine.50.4220
Koh GC, Maude RJ, Paris DH, et al., 2010, Diagnosis of Scrub Typhus. Am J Trop Med Hyg, 82(3): 368-370. 10.4269/ajtmh.2010.09-0233
Wang RD, Dai Y, Gong Y, 2021, Progress in Diagnosis and Treatment of Severe Tsutsugamushi Disease. Chinese Journal of Medicine, 2(28): 0376-2491.
Feng X, Jia X, Ruan Y, Guo L, et al., 2020, Research Progress of Laboratory Diagnosis Methods of Tsutsugamushi Disease. Chinese Journal of Laboratory Medicine, 43(12): 1248-1251.
Evans SM, Rodino KG, Adcox HE, et al., 2018, Orientia Tsutsugamushi Uses Two Ank Effectors to Modulate NF-?b P65 Nuclear Transport and Inhibit NF-?b Transcriptional Activation. PLoS Pathog, 14(5): e1007023. 10.1371/journal.ppat.1007023
Canna SW, Marsh RA, 2020, Pediatric Hemophagocytic Lymphohistiocytosis. Blood, 135(16): 1332-1343. 10.1182/blood.2019000936
Jun GL, Jin Y, et al., 2014, Analysis of Clinical Characteristics of 19 Cases of Hemophagocytic Syndrome Secondary to Tsutsugamushi Disease. Chinese Journal of Pediatrics.
Wang Y, Zhang L, 2019, Progress in Diagnosis and Treatment of Infection Related Hemophagocytic Syndrome. World Clinical Drugs.
Zhang Y, Cui Y, et al., 2013, Pay Attention to the Diagnosis and Treatment of Critical Hemophagocytic Syndrome in Children’s Intensive Care Unit, 5(2): 1671-0282.
Allen CE, Mc Clain KL, Wang Z, 2015, Pathophysiology and epidemiology of hemophagocytic syndrome. Hematology Am Soc Hematol Educ Program, 2015: 177-82.
Tao X, 2015, Plasma Exchange Combined with Chemotherapy in the Treatment of a Child with Hemophagocytic Syndrome and Literature Review. World Latest Medicine Information. 15(55).
Zhang Y, Xiao Z, 2018, Effect of Plasma Exchange Combined with Continuous Blood Purification on Pediatric Hemophagocytic Syndrome. Journal of Practical Shock, 2(4): 223-228.