Progress in the Pathologic Diagnosis of Borderline Follicular Thyroid Tumor
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Keywords

Thyroid gland
Borderline tumor
Follicular tumor
Pathologic diagnosis

DOI

10.26689/par.v5i5.2488

Submitted : 2021-08-31
Accepted : 2021-09-15
Published : 2021-09-30

Abstract

With the progress of science and technology as well as the development of ultrasound technology, more and more thyroid tumors have been found. Follicular tumor is one of the most common thyroid tumors, but borderline follicular tumors are relatively rare. At present, the diagnosis of borderline follicular thyroid tumor is unclear prior to surgery, and it is difficult to identify in frozen section or even conventional section. In order to effectively improve the diagnostic sensitivity and specificity of borderline follicular thyroid tumor, this paper summarizes the new WHO (World Health Organization) classification of borderline follicular thyroid tumor along with diagnostic methods, including clinical fine needle aspiration cytology, histopathology, and molecular biology, and reviews the research progress.

References

Rusinek D, Chmielik E, Krajewska J, et al., 2017, Current Advances in Thyroid Cancer Management – Are We Ready for the Epidemic Rise of Diagnoses?. Int J Mol Sci, 18(8).

Li Y, 2010, Application Value of Ultrasound-Guided Biopsy in the Diagnosis of Nodular Goiter with Thyroid Cancer. Jilin Medical Journal, 31(23): 3871-3872.

Liu Z, Zhou G, Kennichi K, 2016, Biological Behavior of Thyroid Cancer in Thyroid Fine Needle Aspiration with Uncertain Types of Lesions. Chinese Journal of Pathology, 45(6): 423-426.

Daniels GH, 2018, Follicular Thyroid Carcinoma: A Perspective. Thyroid, 28(10): 1229-1242.

Chen Y, 2020, Clinical Study on Diagnosis and Treatment of Thyroid Follicular Tumor. Jilin University, 42(6): 530-534.

Zeng S, Xu P, Guo M, 2020, Clinical Research Progress of Non-Invasive Follicular Thyroid Tumor with Papillary Nucleus. Journal of Shanghai Jiaotong University (Medical Edition), 40(7): 969-973, 968.

Gao M, Wei S, 2019, Progress in Diagnosis and Treatment of Non-Invasive Follicular Thyroid Tumor with Papillary Nucleus. Cancer Prevention and Treatment, 32(12): 1039-1044.

Hamza A, Khawar S, Alrajjal A, et al., 2019, Processing the Entire Capsule in Thyroid Follicular Lesions Improves Diagnostic Accuracy. Annals of Diagnostic Pathology, 39: 21-24.

Fang S, Xiao H, Nikiforov YE, et al., 2019, Changes of Diagnostic Criteria for Non-Invasive Follicular Thyroid Tumor with Papillary Nucleus Features. J Clin Exp Pathol, 35(1): 55.

Lei Y, Pan Y, Yang T, et al., 2019, Recognition and Retrospective Analysis of Borderline Thyroid Tumor. Journal of Clinical and Experimental Pathology, 35(8): 968-971.

Feng Y, Zhang L, Li Q, et al., 2017, Expression and Significance of CK19, Galectin-3, HBME-1 and TPO in Well Differentiated Thyroid Tumors with Undetermined Malignant Potential. Journal of Practical Oncology, 32(4): 362-366.

Tang M, Yang H, Liu P, et al., 2018, Proteomic Analysis of Differentially Expressed Proteins in Well Differentiated Thyroid Tumors with Undetermined Malignant Potential. China Medical Journal, 15(7): 60-65, 181.

Shou YY, Cai LB, Chen LJ, et al., 2012, Expression and Clinical Significance of Galectin-3 and HBME-1 in Well Differentiated Thyroid Tumors with Undetermined Malignant Potential and Follicular Structure. Zhejiang Practical Medicine, 17(4): 243-244, 255.

Zhang S, Feng Z, Yang N, et al., 2020, Clinicopathological Characteristics and Prognosis of 40 Cases of Borderline Thyroid Tumor. Journal of Clinical and Experimental Pathology, 36(10): 1202-1204, 1208.

Papotti M, Rodriguez J, De Pompa R, et al., 2005, Galectin-3 and HBME-1 Expression in Well-Differentiated Thyroid Tumors with Follicular Architecture of Uncertain Malignant Potential. Mod Pathol, 18(4): 541-546.

Wang Y, Xiang L, Zhou P, et al., 2019, Molecular Research Progress of Non-Invasive Follicular Thyroid Tumor with Papillary Carcinomatous Nucleus. Chinese Journal of Basic and Clinical General Surgery, 26(1): 110-115.

Zhao RN, Liu Y, He M, et al., 2020, Clinicopathological Analysis of 6 Cases of Thyroid Non-Invasive Follicular Tumor with Papillary Carcinomatous Nucleus. Journal of Clinical and Experimental Pathology, 36(5): 574-576.

Kim TH, Lee M, Kwon AY, 2018, Molecular Genotyping of the Non-Invasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma. Histopathology, 72(4): 648-661.

Johnson DN, Sadow PM, 2018, Exploration of BRAFV600E as a Diagnostic Adjuvant in the Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP). Hum Pathol, 82: 32-38.

Han M, He Y, Wang Y, et al., 2018, Clinicopathological Analysis of 4 Cases of Non-Invasive Follicular Thyroid Tumor with Papillary Nucleus. Journal of Diagnostic Pathology, 25(11): 750-753.

Yang N, Huang Y, Yan W, et al., 2020, Clinicopathological Characteristics of Non-Invasive Follicular Thyroid Tumor with Papillary Nucleus. Chinese Journal of Oncology, 47(17): 886-889.

Hofman V, Lassalle S, Bonnetaud C, et al., 2009, Thyroid Tumours of Uncertain Malignant Potential: Frequency and Diagnostic Reproducibility. Virchows Arch, 455(1): 21-33.

Zhang Z, Chen T, Yang C, et al., 2019, Clinicopathology of Thyroid Tumor with Undetermined Malignant Potential. Journal of Kunming Medical University, 40(9): 83-88.