Objective: To compare and analyze the clinical diagnostic value of multi-slice spiral CT and enhanced MRI for primary liver cancer (PLC), and to summarize the imaging findings. Methods: The research subjects in this article were 50 patients with PLC who were admitted to our hospital from 2017 April to 2018 September. After the patients were admitted, they were examined by multi-slice spiral CT and enhanced MRI scanning, and the pathological diagnosis results were followed up. Relevant information was reviewed and analyzed. Results: The detection rate of multi-slice spiral CT was higher than that of MRI in the portal venous phase lesion detection. The difference was statistically significant (P<0.05). The detection rate of lesions in the arterial phase and delayed phase was not statistically significant (P>0.05); the diagnostic accuracy of multi-slice spiral CT was 85.96%, and the diagnostic accuracy of enhanced MRI scanning was 91.11%, which was not statistically significant (P>0.05). MRI scans showed the capsules of primary liver cancer better than CT, but the difference was not statistically significant (P>0.05). Conclusion: In conclusion, both multi-slice spiral CT and enhanced MRI can be used for the effective diagnosis of primary liver cancer intrahepatic lesions. The diagnostic value of the two is equivalent, but enhanced MRI has a slightly higher diagnostic accuracy and can be used as the preferred method.