Objective: To study the clinical effect of breast conserving combined with sentinel lymph node biopsy and modified radical mastectomy in patients with early breast cancer. Methods: Female patients with early breast cancer in clinical stage I and II were selected as the main objects of this study, the study period started from July 2017 to July 2020. In the breast conserving and sentinel lymph node biopsy patients, 50 cases were randomly selected as the experimental group; 50 cases in the modified radical mastectomy patients were randomly selected as the control group. The clinical intervention effect of the two groups was analyzed. Results: the perioperative indexes of the experimental group were shorter than those of the control group, the patients recovered faster, the incidence of complications in the experimental group was lower, and the quality of life scores of the experimental group were significantly higher than those of the control group, and the difference was statistically significant, the intervention effect of the experimental group was also better. Conclusion: The application of breast conserving and sentinel lymph node biopsy in the treatment of early breast cancer can promote the recovery of patients, shorten the operation time and reduce the rate of complications, which has significant clinical significance.