Objective: To investigate the clinical outcome of artificial hip replacement for proximal femoral bone tumors. Methods: One hundred patients with proximal femur bone tumors admitted to the hospital for treatment from June 2018 to May 2020 were selected and divided into a control group and an experimental group of 50 patients each using central randomization. The control group received conventional treatment and the experimental group underwent artificial total hip arthroplasty, and the results of treatment were compared between the two groups. Results: The operative time and hospitalization time of the experimental group were shorter than that of the control group, and the blood loss was less than that of the control group; after the replacement surgery, the range of flexion and extension, internal and external rotation activity and abduction activity scores were better than those of the control group; and the total incidence of adverse reactions in the experimental group was 6.0%, which was significantly lower than that of the control group (14.0%). By comparing the treatment effects of the two groups, the differentiation was significant, and P<0.05 was statistically significant. Conclusion: Artificial hip arthroplasty can effectively treat proximal femoral tumors, shorten operative time, hospitalization time and intraoperative bleeding, and alleviate patients' therapeutic pain, which has good promotion value in clinical practice.