Objective: To investigate the clinical efficacy of periodontal sequence in combination with orthodontic treatment of patients with periodontitis. Methods: Retrospective analysis of periodontitis patients (54 cases) treated at our hospital between February 2018 and June 2019. The clinical data of all the enrolled participants were subjected to periodontal serial combined orthodontic treatment, and all the registered participants were observed at the initial consultation, periodontal serial treatment1 Periodontal parameters at the end of months and at the end of orthodontic treatment, serial periodontal treatment and orthodontic treatment for all enrolled individuals, x-rays and Oral examinations were performed, and the results were analyzed. Results: Compared to the initial visit, all enrolled individuals had a higher plaque index (PLI) after 1 month of periodontal treatment and at the end of orthodontic treatment. Bleeding index (BI), periodontal probe depth (PD), and periodontal attachment loss (CAL) levels were all lower than those detected at the initial visit. The difference was statistically significant (P < 0.05); after serial periodontal treatment and orthodontic treatment, the x-ray results showed that the patients' Alveolar bone resorption or regeneration ceased; The results of the oral examination showed that the patient's occlusal relationship improved significantly and basically returned to normal. Status, a masticatory function was significantly improved, and individual tooth loosening due to occlusal trauma was improved considerably. Conclusion: The combination of periodontal sequence and orthodontic treatment of patients with periodontitis is beneficial to enhance periodontal parameters, improve occlusal relationships, and improve masticatory function.