Objective: To investigate the effect of dual-perspective nursing intervention based on safety and comfort needs on the psychological status and safety quality of patients undergoing magnetic resonance imaging (MRI). Methods: A total of 100 patients who received MRI in our hospital from October 2017 to December 2019 were selected and randomly divided into two groups, 50 cases for each group. Routine nursing intervention was performed in the control group, and double-perspective nursing intervention based on safety and comfort needs in addition to routine nursing was performed in the observation group. Psychological status and examination of safety quality were observed and compared between the two groups. Results: The scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) in the observation group were lower than those in the control group after intervention. Meanwhile, the scores of early treatment of dangerous conditions, implementation of safety measures, prevention of accidental injuries, communication of safety information, education of safety knowledge, standardized examination and awareness of self-safety management in the observation group were higher than those in the control group after intervention, and the differences were statistically significant (P < 0.05). Conclusion: Dual-perspective nursing intervention based on safety and comfort needs is effective for patients undergoing MRI examination, which can improve the psychological status of patients and improve the quality of examination safety.