Objective: This article mainly analyzes the risk factors of pressure injury related to tracheal intubation in ICU patients. Methods: This time, the investigation and research were mainly conducted on 110 patients with tracheal intubation received in the ICU of our hospital from June 2020 to June 2021, and the risk factors for related pressure injuries were analyzed. Results: According to statistics, the incidence rate of patients with tracheal intubation-related pressure injury was 23.63%, of which the lip had the highest incidence; the indwelling time of the tracheal tube, the wetness score, the movement force score, and the frictional shear score in the Braden score of the tracheal intubation These are all risk factors for pressure injury related to tracheal intubation (P<0.05). Conclusion: ICU patients have a higher incidence of related pressure injuries during tracheal intubation, so it is necessary to strengthen the care of risk factors and take reasonable and effective measures to prevent them.