Keywords
Carbon dioxide fractional laser
Vitiligo
Submitted : 2023-08-27
Accepted : 2023-09-11
Published : 2023-09-26
Abstract
This paper aims to explore the clinical effect and safety of combined application of 308 nm excimer ultraviolet light and carbon dioxide fractional laser in the treatment of refractory vitiligo. The study was carried out from January 2020 to December 2022. 60 patients with refractory vitiligo were selected and divided into the study group (n = 30) and the control group (n = 30) through the lottery method of medical record envelopes. The patients in the control group were treated with 308 nm excimer ultraviolet light, and the patients in the study group were treated with 308 nm excimer ultraviolet light combined with carbon dioxide fractional laser treatment. The clinical effective rate, leukoplakia area, IgG level, and incidence of adverse reactions were compared between the two groups. The clinical effective rate of the study group was higher than that of the control group (P < 0.05). After treatment, the leukoplakia area of the study group was lower than that of the control group (P < 0.05), and the IgG level of the study group was lower than that of the control group (P < 0.05). The incidence of adverse reactions in the study group was lower than that in the control group (P < 0.05). The combined application of 308 nm excimer ultraviolet light and carbon dioxide fractional laser therapy for patients with refractory vitiligo has a significant effect, can reduce the area of leukoplakia and IgG levels, and has high treatment safety, which can be widely applied in clinical practice.
References
Shi D, 2022, Clinical Effect Analysis of 308nm Excimer Laser Combined with CO2 Fractional Laser and PRP in the Treatment of Stable Vitiligo. Chinese and Foreign Medical, 41(2): 22–25, 29.
Lin M, Liu Y, Liu J, et al., 2021, Clinical Efficacy and Safety Analysis of CO2FL Combined with Compound Betamethasone Package and 308nm Excimer Laser in the Treatment of Stable Vitiligo. Chinese and Foreign Medical Research, 19(22): 45–48.
Shan J, Luo W, Shan K, et al., 2022, Clinical Efficacy and Safety Analysis of CO2FL Combined with Compound Betamethasone Package and 308nm Excimer Laser in the Treatment of Stable Vitiligo. World Latest Medical Information Digest, 22(53): 71–75.
Wang L, 2017, Clinical Efficacy and Safety Evaluation of 308nm Excimer Laser Combined with CO2 Fractional Laser in the Treatment of Vitiligo. Psychologist, 23(35): 110.
Xu W, Liu J, Yang G, 2023, Observation on the Repairing Effect of Compound Glycyrrhizin Tablets Combined with Tacrolimus Ointment and 308nm Excimer Light in the Treatment of Vitiligo Lesions. China Aesthetic Medicine, 32(4):84–87.
Li L, 2023, Clinical Observation of Wuqi Xiaoban Decoction Combined with 308nm Excimer Laser and Tacrolimus in the Treatment of Advanced Vitiligo. Medical Theory and Practice, 36(5): 805–807.
Liu Q, Wang D, Zhang Q, et al., 2023, Observation on the Curative Effect of Fire Acupuncture Combined with 308nm Excimer Light in the Treatment of Stable Vitiligo and its Effect on T Lymphocyte Subsets. Journal of Jiangxi University of Traditional Chinese Medicine, 35(2): 63–66.
Wang X, Li Q, 2023, Effects of 308nm Excimer Laser Combined with Compound Glycyrrhizin Tablets on T Cell Subsets and Serum ICAM-1 and SOD in Patients with Vitiligo. China Medicine Guide, 25(1): 71–75.
Luan C, Hu Y, Chen K, et al., 2022, A Retrospective Study on the Efficacy and Safety of 308nm SQ LED Light and 308nm Excimer Light in the Treatment of Facial Vitiligo. Chinese Journal of Dermatology, 55(1): 16–19.
Wen X, Liu J, Ding M, et al., 202, Clinical Study of Tacrolimus Ointment Combined with 308nm Excimer Light in the Treatment of Adult Facial Vitiligo. Chinese Cosmetic Medicine, 31(6): 13–16.
Yu T, Wu Y, Lu Z, 2023, Efficacy of Medium-Wave High-Energy Ultraviolet Rays Combined with Fractional CO2 Laser in the Treatment of Refractory Vitiligo and Analysis of Dermoscopic Index Evaluation. Chinese Cosmetic Medicine, 32(3): 83–86.
Hao R, Yan J, 2023, The Effect of Ultra-Pulse CO2 Fractional Laser Combined with Tacrolimus Ointment in the Treatment of Vitiligo Vulgaris and its Influence on Serum IL-17 and IL-23 Levels. Clinical Medicine Research and Practice, 8(4): 87–90.
Zhang J, Guo C, 2022, Clinical Efficacy and Safety Observation of CO2 Fractional Laser Combined with Triamcinolone Acetonide Injection in the Treatment of Stable Vitiligo. Guizhou Medicine, 46(4): 590–591.
Wang L, Wu T, Mei Y, 2022, Observation on Curative Effect and Adverse Reactions of CO2 Fractional Laser Combined with Tacrolimus Ointment and Tacrolimus Ointment Alone in the Treatment of Localized Vitiligo. Guizhou Medicine, 46(11): 1697–1698.
Zhao F, 2022, Therapeutic Effect and Adverse Reactions of Excimer Laser Therapeutic Apparatus Combined with CO2 Fractional Laser Therapeutic Apparatus for Vitiligo. Modern Instruments and Medicine, 28(1): 70–72.