Cardiovascular and Diabetes Risk in Preschoolers


Preschool children
Risk factors
Cardiovascular disease
Type 2 diabetes




Objective: To perform an exploratory analysis of possible alterations in clinical markers of cardiovascular risk and type 2 diabetes in preschoolers living in urban and suburban areas of the municipality of Hermosillo, Sonora, Northwest Mexico. Methods: An observational and cross-sectional study was carried out on children from urban and suburban areas. Their weight, height, waist circumference, body fat percentage, and blood pressure were measured, and their lipid profile, glucose, and insulin concentrations were evaluated. Results: Eighty-two children with an average age of five were included in the study; 48 from the conurbation and 34 from the urban area. We found that malnutrition, overweight, and high body fat percentage (27 ± 0.52) coexist. In the suburban area, there was a higher percentage of children with pre-hypertension and alterations in lipids: elevated triglycerides (35%) and low HDL-c (25%) (p < 0.01). In the urban area, there was a higher percentage of children with altered glucose (12%), elevated insulin concentrations, and insulin resistance. Conclusion: The findings of this study show that cardiovascular risk factors and type 2 diabetes are prevalent in children aged three to six living in urban and conurbation areas of Hermosillo, Sonora.


Van Vliet M, Heymans MW, von Rosenstiel IA, et al., 2011, Cardiometabolic Risk Varia¬bles in Overweight and Obese Children: A Worldwide Compa¬rison. Cardiovasc Diabetol, 10: 106.

Getz GS, Reardon CA, 2007, Nutrition and Cardiovascular Di¬sease. Arterioscler Thromb Vasc Biol, 27(12): 2499–2506.

Johannsson E, Arngrimsson SA, Thorsdottir I, et al., 2006, Tracking of Overweight from Early Childhood to Adolescen¬ce in Cohorts Born 1988 and 1994: Overweight in a High Birth Weight Population. Int J Obes, 30(8): 1265–1271.

Timpka T, Angbratt M, Bolme P, et al., 2007, A High-precision Protocol for Identification of Preschool Children at Risk for Persisting Obesity. PLoS ONE, 2(6): e535.

Juonala M, Magnussen CG, Berenson GS, et al., 2011, Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors. N Engl J Med, 365: 1876–1885.

Tamir I, Heiss G, Glueck CJ, et al., 1981, Lipid and Lipoprotein Distributions in White Children Ages 6-19 Yr. The Lipid Research Clinics Program Prevalence Study. Int J Chronic Dis, 34(1): 27–39.

Newman III WP, Freedman DS, Voors AW, et al., 1986, Relation of Lipoprotein Levels and Systolic Blood Pressure to Early Atherosclerosis. N Engl J Med, 314(3): 138–144.

Sanchez-Bayle M, Gonzalez-Requejo A, Ruiz-Jarabo C, et al., 1996, Serum Lipids and Apolipoproteins in Spanish Children and Adolescents: A 5 Year Follow-up. Acta Paediatrica, 85(3): 292–294.

Velasquez E, Baron MA, Solano L, et al., 2006, Perfil Lipidico en Preescolares Venezolanos Segun Nivel Socioeconomico [Lipid Profile in Venezuelan Preschoolers According to Socioeconomic Level]. Arch Latinoam Nutr, 56(1): 22–28.

Acosta Garcia E, 2012, Obesidad, Tejido Adiposo y Resistencia a la Insulina [Obesity, Adipose Tissue and Insulin Resistance]. Acta Bioquím Clín Latinoam, 46(2): 183–194.

Ramirez-Murillo C, Guillot-Sanchez E, Artalejo E, et al., 2015, Prevalence of Metabolic Syndrome Diag¬nosed by Three Different Criteria in School-Aged Children from Rural and Urban Areas of Northwest Mexico. J Metab Syndr, 4: 2–9.

Gutierrez JP, Rivera-Dommarco J, Shamah-Levy T, et al., 2012, EncueSta Nacional de Salud y Nutricion 2012 [National Health and Nutrition Survey 2012]. Instituto Nacional de Salud Publica [National Institute of Public Health], Cuernavaca, Mexico.

Jelliffe TDB, Jelliffe EFP, 1989, Community Nutritional As¬sessment: With Special Reference to Less Technically De¬veloped Countries, Oxford University Press, Oxford, United Kingdom.

WHO, 2009, Anthro para Computadoras Personales, Version 3, 2009: Software Para Evaluar el Crecimiento y Desarrollo de los Ninos del Mundo [Anthro for Personal Computers, Version 3, 2009: Software to Assess the Growth and Development of the World’s Children]. World Health Organization, Geneva.

Fernandez JR, Redden DT, Pietrobelli A, et al., 2004, Waist Circumference Percentiles in Nationally Representative Samples of African-American, European-American, and Mexican-American Children and Adolescents. J Pediatr, 145(4): 439–444.

Ramirez-Lopez E, Grijalva-Haro MI, Valencia ME, et al., 2005, Impacto de un Programa de Desayunos Escolares en la Prevalencia de Obesidad y Factores de Riesgo Cardiovascular en Ninos Sonorenses [Impact of a School Breakfast Program on the Prevalence of Obesity and Cardiovascular Risk Factors in Sonoran Children]. Salud Publica Mex, 47(2): 126–133.

NHBPEP, 2005, National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The Fourth Report on the Diagnosis, Evalua¬tion, and Treatment of High Blood Pressure in Children and Adolescents. National Institutes of Health, Bethesda, MD.

Friedewald WT, Levy RI, Fredrickson DS, 1972, Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge. Clin Chem, 18(6): 499–502.

Daniels SR, Greer F, Committee on Nutrition, 2008, Lipid Scree¬ning and Cardiovascular Health in Childhood. Pediatric, 122(1): 198–208.

ADA, 2016, Classification and Diagnosis of Diabetes. Diabetes Care, 39: S13–S22.

García-Cuartero B, Garcia-Lacalle C, Jimenez-Lobo C, et al., 2007, Indice HOMA y QUICKI, Insulina y Peptido C en Ninos Sanos. Puntos de Corte de Riesgo Cardiovascular [HOMA and QUICKI Index, Insulin and C-peptide in Healthy Children. Cut-off Points for Cardiovascular Risk]. An Pediatr (Barc.), 66(5): 481–490.

Freedman D, Wang J, Thornton J, et al., 2009, Classification of Body Fatness by Body Mass Index-for-Age Categories Among Children. Arch Pediatr Adolesc Med, 163(9): 805–811.

WHO, 2021, Enfermedades cardiovasculares [Cardiovascular Diseases],

De Onis M, Blossner M, Borghi E, 2010, Global Prevalence and Trends of Overweight and Obesity among Preschool Children. Am J Clin Nutr, 92(5): 1257–1264.

Chiarelli F, Marcovecchio ML, 2008, Insulin Resistance and Obesity in Childhood. Eur. J. Endocrinol, 159: S67–S74.

Barker DJP, 1997, Fetal Nutrition and Cardiovascular Disease in Later Life. Br. Med. Bull, 53(1): 96–108.

Mackness B, Mackness M, 2010, Anti-Inflammatory Properties of Paraoxonase-1 in Atherosclerosis, in Paraoxonases in Inflammation, Infection, and Toxicology, Humana Press, 143–151.

Reaven P, Nader PR, Berry C, et al., 1998, Cardiovascular Disease Insulin Risk in Mexican-American and Anglo-American Children and Mothers. Pediatrics, 101(4): E12.

Kelishadi R, Asgary S, Bashardoust N, Naderi GA, et al., 2002, Atherosclerosis Risk Factors in Children and Adolescents With or Without Family History of Premature Coronary Artery Disease. Med Sci Monitor, 8(6): CR425-CR429.

Barja S, Arteaga A, Acosta A, 2003, Resistencia Insulinica y Otras Expresiones del Sindrome Metabolico en Ninos Obesos Chilenos [Insulin Resistance and Other Expressions of Metabolic Syndrome in Obese Chilean Children.]. Rev Med Chil, 131(3): 259–268.

Ayala-Mendivil A, 2016, Presencia de Higado Graso No Alcoholico en Ninos Escolares Sonorenses, Asociada al Consumo de Azucares Simples y Grasa Nutricion Humana [Presence of Non-Alcoholic Fatty Liver in Sonorens School Children, Associated with the Consumption of Simple Sugars and Fat]. Centro de Investigacion en Alimentacion y Desarrollo, A.C. [Food and Development Research Center, A.C], Hermosillo, Sonora.

Zimmet P, Alberti G, Kaufman F, et al., 2007, The Metabolic Syndrome in Children and Ado¬lescents: The IDF Consensus. Pediatric Diabetes 8(5): 299–306.