Keywords
Osteoporosis
Curcumin
Therapeutic role
Submitted : 2024-05-24
Accepted : 2024-06-08
Published : 2024-06-23
Abstract
Osteoporosis is a common bone disease that occurs when the body makes too little bone, loses too much bone, or both. This makes the bones weak and more likely to break. Scientists are studying how to treat osteoporosis using natural substances found in food and medicine. One of these substances is curcumin, which comes from the roots of plants in the ginger family. Curcumin has different components like phenols, terpenes, and flavonoids. Research shows that curcumin can help treat osteoporosis by affecting how cells in the bones grow and change. It can also interfere with the signals that tell the body to make more bone or break down bone. This helps to prevent and treat osteoporosis in multiple ways. Studying how curcumin works against osteoporosis can help us find new ways to prevent and treat this condition.
References
Inchingolo AD, Inchingolo AM, Malcangi G, et al., 2022, Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism—A Systematic Review. Nutrients, 14(17): 3519.
Coulombe P, Meloche S, 2007, Atypical Mitogen-Activated Protein Kinases: Structure, Regulation and Functions. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1773(8): 1376–1387. https://doi.org/10.1016/j.bbamcr.2006.11.001
Fruman DA, Chiu H, Hopkins BD, et al., 2017, The PI3K Pathway in Human Disease. Cell, 170(4): 605–635. https://doi.org/10.1016/j.cell.2017.07.029
Esatbeyoglu T, Huebbe P, Ernst IM, et al., 2012, Curcumin—From Molecule to Biological Function. Angew Chem Int Ed Engl, 51(22): 5308–5332. https://doi.org/10.1002/anie.201107724
Sharifi-Rad J, Rayess YE, Rizk AA, et al., 2020, Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications. Frontiers in Pharmacology, (11): 01021. https://doi.org/10.3389/fphar.2020.01021
Dana PM, Sadoughi F, Mansournia MA, et al., 2021, Targeting Wnt Signaling Pathway by Polyphenols: Implication for Aging and Age-Related Diseases. Biogerontology, 22(5): 479–494. https://doi.org/10.1007/s10522-021-09934-x
Croce JC, McClay DR, 2009, Evolution of the Wnt Pathways, in Vincan E, (ed.), Wnt Signaling, Humana Press, Totowa, NJ, 3–18.
Saito-Diaz K, Chen TW, Wang X, et al., 2013, The Way Wnt Works: Components and Mechanism. Growth Factors, 31(1): 1–31. https://doi.org/10.3109/08977194.2012.752737
Janda CY, Waghray D, Levin AM, et al., 2012, Structural Basis of Wnt Recognition by Frizzled. Science, 337(6090): 59–64. https://doi.org/10.1126/science.1222879
Amjadi-Moheb F, Akhavan-Niaki H, 2019, Wnt Signaling Pathway in Osteoporosis: Epigenetic Regulation, Interaction with Other Signaling Pathways, and Therapeutic Promises. J Cell Physiol, 234(9): 14641–14650. https://doi.org/10.1002/jcp.28207
Muruganandan S, Roman AA, Sinal CJ, 2009, Adipocyte Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells: Cross Talk with the Osteoblastogenic Program. Cellular and Molecular Life Sciences, 66(2): 236–253. https://doi.org/10.1007/s00018-008-8429-z
Chen Z, Xue J, Shen T, et al., 2016, Curcumin Alleviates Glucocorticoid-Induced Osteoporosis through the Regulation of the Wnt Signaling Pathway. International Journal of Molecular Medicine, 37(2): 329–338.
Yu H, Lin L, Zhang Z, et al., 2020, Targeting NF-?B Pathway for the Therapy of Diseases: Mechanism and Clinical Study. Signal Transduct Target Ther, 5(1): 209. https://doi.org/10.1038/s41392-020-00312-6
Uings I, Farrow S, 2000, Cell Receptors and Cell Signalling. Molecular Pathology, 53(6): 295.
Su Z, Yao B, Liu G, et al., 2024, Polyphenols as Potential Preventers of Osteoporosis: A Comprehensive Review on Antioxidant and Anti-Inflammatory Effects, Molecular Mechanisms, and Signal Pathways in Bone Metabolism. The Journal of Nutritional Biochemistry, (123): 109488. https://doi.org/10.1016/j.jnutbio.2023.109488
Yang S, Sun Y, Kapilevich L, et al., 2023, Protective Effects of Curcumin against Osteoporosis and Its Molecular Mechanisms: A Recent Review in Preclinical Trials. Front Pharmacol, (14): 1249418. https://doi.org/10.3389/fphar.2023.1249418