Keywords
Estrogen and progesterone
Guishen Yugong Decoction
Serum sex hormones
Curative effect
Submitted : 2023-02-26
Accepted : 2023-03-13
Published : 2023-03-28
Abstract
Objective: To analyze the therapeutic effect of Guishen Yugong Decoction + sequential hormone (estrogen and progesterone) replacement therapy and its effect on serum sex hormones in patients with premature ovarian failure. Methods: From July 2020 to July 2022, 100 patients with premature ovarian failure were included in the study. Random number table method was used to divide the patients into groups: the control group received sequential hormone replacement therapy, whereas the treatment group received Guishen Yugong Decoction + sequential hormone replacement therapy. The curative effect, traditional Chinese medicine (TCM) syndrome scores, serum sex hormone levels, and incidence of adverse reactions of both groups of patients were compared. Results: The total effective rate in the treatment group was higher than that in the control group, P < 0.05; the TCM syndrome scores in the treatment group were lower than those in the control group, P < 0.05; the serum sex hormone indices in the treatment group were better than those in the control group (P < 0.05); the treatment group had lower incidence of adverse reactions, as compared to the control group (P < 0.05). Conclusion: Guishen Yugong Decoction + sequential hormone replacement therapy can regulate serum sex hormone levels and relieve symptoms of premature ovarian failure. This treatment is not only effective, but also safe for clinical use.
References
Guo Y, Wu X, 2022, Effect of Zishen Yikun Qingxin Decoction Combined with Dydrogesterone on Sex Hormone Levels and Immune Indicators in Patients with Premature Ovarian Failure. Chinese Practical Medicine, 17(17): 161–163.
Xu P, 2022, The Effect of Modified Buyin Yishen Decoction Combined with Estrogen and Progesterone Sequential Therapy in the Treatment of Premature Ovarian Failure and Its Impact on INHB and ?-EP Levels. Clinical Medicine Research and Practice, 7(16): 138–141.
Cao Z, 2014, Chinese Obstetrics and Gynecology 3rd Edition, People’s Medical Publishing House, Beijing, 2592–2593.
Zheng X, 2002, Guiding Principles for Clinical Research of New Drugs of Traditional Chinese Medicine (Trial Implementation), China Medical Science and Technology Press, Beijing, 243 + 383–389.
Yang D, 2022, Clinical Curative Effect of Zishen Yutai Pill Combined with Estradiol Valerate on Female Premature Ovarian Failure and the Influence of Estrogen Level. Reflexology and Rehabilitation Medicine, 3(07): 14–16.
Zhang J, Pan L, Guo F, 2022, Efficacy of Yishen Fuchao Decoction in Treating Patients with Premature Ovarian Failure/Ovarian Insufficiency and Its Effect on Serum Sex Hormone Levels. Laboratory Medicine and Clinic, 19(03): 371–374.
Li Y, 2021, Clinical Efficacy of Acupuncture and Medicine Combined with Estrogen and Progesterone in the Treatment of Premature Ovarian Failure of Kidney Deficiency and Blood Stasis Type and Its Influence on Pregnancy Outcome. Hubei Journal of Traditional Chinese Medicine, 43(12): 16–19.
Wan N, Li S, Sun H, et al., 2021, Clinical Efficacy of Warming Acupuncture and Moxibustion Combined with Danggui Guizhi Decoction in the Treatment of Premature Ovarian Failure and Its Influence on Ovarian Blood Flow. Journal of Hubei University of Traditional Chinese Medicine, 23(03): 87–89.
Liu L, Wang J, Wang M, et al., 2021, Effects of Sequential Therapy of Modified Xiaoyao Powder Combined with Estrogen and Progesterone on Clinical Curative Effect and Serum FSH, LH, PRL, AMH Levels in Patients with Secondary Amenorrhea. Analysis and Clinic, 28(02): 273–277 + 325.
Wang X, 2021, Effects of Platelet-Rich Plasma Combined with Estrogen and Progesterone on Ovarian Reserve Function and Serum FSH, LH, PGE2 Levels in Patients with Premature Ovarian Failure. Modern Medicine and Health Research Electronic Journal, 5(01): 48–50.
Yang J, Tang L, Wei H, et al., 2020, Efficacy of Zishen Yutai Pills Combined with Estradiol Valerate in the Treatment of Premature Ovarian Failure in Women and Its Effect on Serum Estrogen Levels. Chongqing Medicine, 49(22): 3803–3806.
Wang C, Yang L, Chen W, et al., 2020, Clinical Efficacy of Erxian Decoction Combined with Yougui Decoction Combined with Sequential Therapy on Patients with Premature Ovarian Failure of Kidney Yang Deficiency. Chinese Patent Medicine, 42(07): 1760–1764.
Wang X, 2020, Observation on the Clinical Effect of Self-Made Kangshou Yishen Prescription Combined with Estrogen and Progesterone Sequential Therapy in the Treatment of Premature Ovarian Failure. Electronic Journal of Practical Gynecology Endocrinology, 7(16): 68–69.
Liu Y, Wang C, Jin Q, 2019, The Curative Effect of Kuntai Capsules Combined with Estrogen and Progesterone Sequential Therapy in the Treatment of Premature Ovarian Failure and Its Influence on the Balance of Treg and Th17 and the Level of Cytokines. China Maternal and Child Health, 34(22): 5308–5311.
Xu M, Wei Y, 2019, Effects of Combined Therapy of Chaoshuai Fuyuan Decoction and Progesterone on Serum Follicle-Stimulating Hormone, Prolactin and Ovarian Reserve Function in Patients with Premature Ovarian Failure. China Maternal and Child Health Care, 34(10): 2319–2323.